It implies controlled studies in human beings, with defined endpoints, that tell us whether a compound does what it is claimed to do
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Of course, there is some degree of variability in results with these types of treatments, because how well your body reacts depends upon its max output ability for collagen creation, which declines with age and is always less for certain people (genetic predisposition)
CRPC closely associates with metastasis and rapid progression, typically exhibiting enhanced invasiveness and metastatic potential that sharply deteriorate prognosis
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