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10,11 The intake of protein and amino acids regulates IGF-1 circulating in the body

This powerful molecule plays a vital role in detoxification, immune support, and cellular health

Endurance training activates key regulators such as PGC-1, NRF1 and TFAM, leading to the production of new, functional mitochondria

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Most findings are derived from in vitro models, underscoring the urgent need for robust in vivo validation in relevant preclinical models

However, iron chelators including deferoxamine (DFO), deferiprone (DFP), and deferasirox (DFX) generally lack tissue and cellular specificity, often resulting in the non-selective depletion of physiologically essential iron