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Statistical analyses were performed in R v4.1.2 (37) using libraries nlme (Reference Pinheiro and Bates38) , multcomp (Reference Hothorn, Bretz and Westfall39) , lme4 and ggplot2 (Reference Wickham40)

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The beginning and advancement of ferroptosis are primarily governed by lipid ROS, ferrous iron, and GPX4 activity, where increased ferrous iron levels and reduced GPX4 activity signify the commencement of ferroptosis [79]

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