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It acts on fibroblasts to stimulate collagen and elastin production, accelerates wound healing and tissue remodeling, supports hair follicle cycling, and has well-documented anti-inflammatory effects across multiple tissue types

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Thus, proteins containing unfolded or unstructured regions, which can independently enter into the 20S proteasomes narrow aperture, can be passively degraded (Ben-Nissan and Sharon, 2014a

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doi: 10.3233/ADR-170019

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