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VEGF tumorigenesis was avoided and counteracted (Sikiric et al., 1997c), and inhibition of the growth of several tumor lines and counteraction of tumor cachexia (Kang et al., 2018) and counteraction of the uncontrolled cell proliferation (Ki-67 overexpression counteracted) (Sever et al., 2019) were observed
Preclinical toxicology studies in animals showed no concerning findings with chronic administration, but human long-term data would strengthen confidence in extended protocols
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Results will likely be slower and less dramatic than injectable protocols, but meaningful improvement remains possible