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A buildup of ROS such as H 2 O 2 (hydrogen peroxide) and O 2 - (superoxide anion) can lead to changes in metal homeostasis or oxidation states of protein metal complexes, such as the release of Fe from ferratin or the reduction of iron in cytochrome C [119]

Nature Biotechnology , 15 (8), 778783

We further point out that there are there few patients in this study ( n = 7) who were on insulin, hence it is unclear if the observations described here extend to those in whom insulin insufficiency is severe

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"Malignant Pleural Mesothelioma: M.D