Lifestyle smoking, alcohol, obesity, tobacco produce increased free radicals
She may also have trouble conceiving if her partner does not have healthy sperm in adequate numbers
Like other 5-ARIs commercially used for hair regrowth, such as finasteride and dutasteride, progesterone inhibits the 5-alpha reductase enzyme that is responsible for converting testosterone to dihydrotestosterone (DHT)
doi: 10.1155/2020/9879517

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The strongest data comes from Harshini Neelakantan, Stan Watowich, and colleagues at the University of Texas Medical Branch (UTMB)