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The phase 1b, 16-week, multiple-dose ascending trial (NCT05613387) showed a mean body weight reduction of 4.8%, 8.6% and 8.3% at OW doses of up to 2.4 mg, 4.8 mg and 9.0 mg, respectively [116]

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In addition to its effects on hepatic glucose and lipid homeostasis and adipose tissue lipid homeostasis, metformin exerts effects in the intestines, pancreas, vascular endothelial cells, and in cancer cells

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Effect of exercise training on plasma visfatin and eotaxin levels