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In certain embodiments the formulation or composition provides immediate release of at least one active pharmaceutical ingredient

L. I. Fedoreyeva, I. I. Kireev, V. Kh. Khavinson, and B. F. Vanyushin, Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA, Pleiades Publishing Ltd, Nov. 2011. doi: 10.1134/s0006297911110022

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In patients receiving multiple transplants, and who are on cyclosporine, rifampicin cannot be used as it reduces the concentration of cyclosporine very substantially as a result of hepatic enzyme induction