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Membrane excitation is often driven by channel permeability to Ca 2+

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In Russian clinical use, Semax nasal solution for ischemic stroke has been administered at roughly 6,00018,000 mcg per day (618 mg), with one non-randomized post-stroke study using 6,000 mcg/day intranasally delivered as two ten-day courses and reporting increases in plasma BDNF alongside functional-scale improvements