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YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) acts as a recognition protein for m6A and promotes translation of m6A-modified mRNAs, thereby regulating downstream gene expression [12, 13]

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Radiotherapy retains only a palliative role because of relative radioresistance and dose-limiting toxicity to adjacent bowel [56]

Phase II: Maintenance and Consolidation (Weeks 5 8) This phase transitions to a lower TB-500 maintenance dose to sustain the systemic environment while continuing the local BPC-157 signal

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