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However, this restriction may also be part of the reason menthol bans in the US have been unsuccessful, with priority being given to the restriction of e-cigarettes due to intense lobbying from US tobacco companies, who have historically been a very powerful sector of the market

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These tests have continued, despite not being required by federal regulations, their inapplicability to human smokers, and the existence of superior non-animal testing methods.

In a multivariate analysis using FMD as the index, smoking was also confirmed to be an independent risk factor for vascular endothelial dysfunction [59]

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