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The initial dose of amlodipine was 5 mg for 2 weeks with forced titration to 10 mg for 2 weeks, followed by the optional addition of hydrochlorothiazide 12.5 mg for 4 weeks

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In the Phase 2 trial, 72% of participants who had prediabetes at the start had normal glycated hemoglobin levels at 48 weeks, compared to just 22% on placebo

Preliminary data from in vitro cell migration assays suggest that simultaneous exposure to both peptides may lead to additive effects, but these results require confirmation in controlled animal studies

However, more research is needed to confirm its efficacy in humans (8)

Disposal of used vials and syringes follows standard sharps safety protocols