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Notably, in various clinical studies, DPP1 inhibitor treatment groups did not show significant increases in serious infection risk compared to placebo groups

While agonist peptides based on either scaffold are potent in rat obesity models 2,10,11,12,13 , only a transient weight loss effect is observed with sCT in mouse diet-induced obesity (DIO) models 14 , indicating that there may be distinctions in the mode of action of individual dual agonists

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