Activation of FXR in dendritic cells, macrophages, and natural killer T (NKT) cells suppresses the NF-B and NLRP3 inflammasome pathways, thereby attenuating the secretion of pro-inflammatory cytokines (e.g., TNF-, IL-6, and IL-1) while promoting the release of the anti-inflammatory mediator IL-10
Similarly, SYNCRIP depletion in U373 cells led to an overall downregulation of EMT-associated markers (Figure 8F-G)
Additionally, GHK-Cu has potent anti-inflammatory effects, suppressing TGF- and TNF- while stimulating VEGF for angiogenesis
doi: 10.3390/molecules27248855 29 KimR-OJoM-ASongJKimI-CYoonSKimW-K
Hitting one or two hallmarks is not a strategy
doi:10.1111/j.1472-765X.2008.02352.x Liang G, Liao X, Du G, Chen J (2008c) Elevated glutathione production by adding precursor amino acids coupled with ATP in high cell density cultivation of Candida utilis