ROS, related to the increased expression of matrix metalloproteinases (Wunderli et al., 2020), activate several pathways, including the c-Jun N-terminal kinase (JNK) (Wang et al., 2007) and NF-B pathways ( We found that dexamethasone mitigated fluoroquinolone-induced oxidative stress primarily through the upregulation of GPX3, an antioxidant belonging to the glutathione peroxidase family
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The broad appeal of these drugs is showcased by the Food and Drug Administrations approval of electrophilic drugs that act by forming covalent bonds against cancer-relevant targets such as BTK 30 , EGFR 31 or KRAS G12C (ref
doi: 10.1080/13880209.2022.2037663
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