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In fact, the GLP- 1 receptor-cAMP-PKA axis stimulates the growth of beta cells by activating the transducer of regulated cAMP response element-binding protein (CREB) (TORC2) and the expression of the CREB and insulin receptor substrate 2 genes [57] Additionally, by boosting bcl- 2 activity and blocking the proapoptotic Bax, activated CREB also supports beta cell survival [58]

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Some helpful bacteria in the stomach can accelerate the breakdown and creation of bioactive molecules with antioxidant capabilities from dietary antioxidants, such as polyphenols found in fruits and vegetables

In contrast, COX-2 overexpression induced by the agonist rebamipide inhibited the apoptosis of IECs induced by Giardia infection

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