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When caloric restriction is present, mammals synthesise less IGF-1 and its synthesis in the liver is refractory to GH stimulation [128130]

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Some maintain their weight through sustained dietary and exercise modifications

VEGF upregulation, nitric oxide synthesis, collagen deposition

doses over ~1 mg/day are not associated with added benefit

Probably safe to use if: sealed lyophilized vial at controlled room temperature for less than 1 week, brief reconstituted exposure under 2 hours, no visible changes, and peptide responds normally on initial test dose