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[175] reported that after treatment of rat primary neurons with methotrexate, a folate antagonist, the levels of PP2A methylation decreased and phosphorylated tau, APP, and -secretase were increased

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Methylenetetrahydrofolate donates the C1 center required for the biosynthesis of dTMP (2-deoxythymidine-5-phosphate) from dUMP (2-deoxyuridine-5-phosphate)

Structure assignment of the C-terminal loop was initially based on the best interpretable density region of the two complexes of the orthorhombic crystal forms

doi: 10.2967/jnumed.108.059998