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10.1002/pmic.201800060 518 SantambrogioC.PonziniE.GrandoriR

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While it is not clear how this translates to the kinetics of cAMP production in cells expressing individual receptors, the divergence in peptide responses across each receptor is consistent with the dynamic conformational differences that were observed structurally for individual AMYRs bound to distinct peptides

Moreover, this effect is combined to a downregulation of the expression of senescence-associated cytokines in the second model and an improvement of mice physical condition in the third model, respectively 37

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