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If biomarkers show high oxidative stress, evening dosing (24 PM) may also be beneficial
Doctors rarely ask (and patients rarely volunteer) information about their eating habits
Similarly, in a diabetic neuropathy mouse model, topiramate administration (10 or 30 mg/kg) led to a significant, dose-dependent reduction in spinal cord levels of TNF- and IL-1 (Motaghinejad et al., 2016)
Second, the information gatekeeping model broke down just as institutional trust collapsed in the wake of COVID
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