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The specific methodology is as follows: Newly acquired mice were acclimatized in the animal facility for at least one week, then placed on a metal grid for 12 h each day in the experimental room (8:00 AM-8:00 PM), and the fecal output was recorded

The hepatic extraction ratio refers to the fraction of drug removed from the blood on a single pass through the liver, a value which is equal to 1-f H

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