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Neuroscience (2008) 156:56379

Animal models, especially gene knockout and transgenic models, have played an indispensable role in mechanistic verification, confirming the causal relationship between key inflammatory mediators (e.g., TNF-) and testicular-penile damage in preclinical settings, and providing a preclinical platform for evaluating the efficacy of potential therapeutic agents (210)

The "fire" of inflammation is gradually dampened over the following weeks heel pain eases and most patients return to their normal activity with a short course of stretching

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