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Methylation reactions are essential for the metabolism of components of the myelin sheath of nerve cells, as well as for synthesis and metabolism of neurotransmitters (22)

Oxidative stress occurs when the balance between oxidant and antioxidants is damaged 37,38

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These models could further be leveraged to investigate if NSC-secreted factors modulate the gut microbiomes metabolic output or vice versa, providing a mechanistic link between the central and peripheral effects observed in our study

The dosage per the HCPCS descriptor is the minimum dosage and is considered 1 unit

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