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The toxins from smoke cause constriction of blood vessels, causing dryness and irritation

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As the authors note, "Understanding what leads to the differences between these types of studies is important to optimize the public health potential and ways to deliver these interventions." Per the PLOS One study, "evidence from NRT studies suggests that discontinuation of a cessation product is often associated with relapse to smoking." As in nicotine lozenge studies where the treatment period was 6 months, imagine declaring victory while the chemical stimulating the active groups brain dopamine pathways is still circulating in their bloodstream