79,105 Advanced diagnostic methods involve skin biopsy for intraepidermal nerve fiber density (IENFD), 87,104 quantitative sensory testing (QST) for temperature and pain thresholds, corneal confocal microscopy for early small fiber damage, 19,106 and MRN for detailed imaging of nerve structures
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Furthermore, the study was limited to short-term assessments, focusing primarily on biochemical, histological, and selected molecular markers
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