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For precision psychiatry to work we need substantial investment in the discovery and development of biomarkers which has not yet materialized

There was an average 73 fold increase in PRKCSH protein kinase C substrate 80 KH (PRKCSH) (log2 fold = 6.191, P = 0.031), 33 fold increase CALU (log2 fold = 5.026, P = 0.007), 16 fold increase in calreticulin (CALR) (log2 fold = 3.958, P = 0.020), 13 fold increase in insulin-like growth factor-binding protein 4 (IGFBP4) (log2 fold = 3.728, P = 0.033), tenfold increase in semaphorin 4B (SEMA4B) (log2 fold = 3.386, P = 0.020), sixfold increase in H2B clustered histone 3 (HIST1H2BB) (log2 fold = 2.656, P = 0.044), H2B clustered histone 5 (HIST1H2BD) (log2 fold = 2.620, P = 0.044), and H2B clustered histone 1 (HIST1H2BA) (log2 fold = 2.565, P = 0.020)

LaminB1 (BS3547) primary antibody was obtained from BioWorld (Nanjing, Jiangshu, China)

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