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To further enhance the BBB properties of the models, the medium was supplemented with cARLA (250 M 8-(4-chlorophenylthio)adenosine 3,5-cyclic monophosphate sodium salt, 17.5 M Ro-20-1724, 3 mM LiCl, 3 M A83-01

Its most significant and well-understood roles are: Collagen synthesis: Vitamin C is an essential co-factor for the enzymes prolyl hydroxylase and lysyl hydroxylase, which are required to stabilise the triple-helix structure of collagen fibres

In some embodiments, the use of an appropriate thermosetting polymer and an appropriate copolymer (e.g., a gelling agent) in combination with a specific pH range for the formulation allows for high temperature sterilization of formulations described with substantially no degradation of the therapeutic agent or the polymeric excipients

Internist (Berl) 21(7):371-5, 1980

Science 275 , 17901792 (1997)

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