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Published pharmacokinetic databases such as the allometric scaling review in Drug Metabolism Reviews provide correction factors for specific peptide classes

SURMOUNT-1 Investigators

REDEFINE 2 (Phase 3a, NEJM 2025) Davies et al., n=1,206, 68 weeks, T2D + BMI 27

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However, given the associated risks of cardiovascular disease and various cancers, the benefits of these medications, such as better glycemic control, weight loss and improvement in cardiometabolic risk factors as well as other obesity complications, appear to outweigh the risks for most adults with obesity [143, 153]