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reports grants from the Fondo de Investigaciones Sanitario (FIS), Instituto de Salud Carlos III (grant numbers PI18/00335, PI22/00758, ICI23/00032) and the CIBERNED program (Program 1, Alzheimer Disease and SIGNAL study, www.signalstudy.es), partly jointly funded by Fondo Europeo de Desarrollo Regional, Unin Europea, Una manera de hacer Europa