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Chen PI, Cao A, Miyagawa K, Tojais NF, Hennigs JK, Li CG, et al

doi:10.1016/j.coph.2005.11.005

They are extremely common, affecting a significant proportion of UK adults at some point in their lives, particularly during pregnancy, after childbirth, or as a result of constipation, prolonged straining, sitting for long periods, or simply ageing

Kornblau SM, Gandhi V, Andreeff HM, Beran M, Kantarjian HM, Koller CA, O'Brien S, Plunkett W, Estey E

CIH also increased the level of oxidative stress markers 8-OHdG and IL-6 and decreased SOD levels

In laboratory and animal studies, researchers have examined how it interacts with pathways involved in blood vessel formation and tissue repair