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One of the primary reactions of methylcobalamin in the body is to convert homocysteine to methionine high homocysteine levels are undesirable and known to be an indicator of heart disease and stroke risk due to the fact free homocysteine in the blood causes sclerosis of the arteries, putting strain on the vascular system and the heart

In some settings it may be used in injectable or wound-healing protocols

However, toxicity has also been decreased while the circulating plasma half-life has increased, and therefore, higher doses of these agents can be administered

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444 Declines in dementia risk have been attributed to increasing levels of education and improved control of cardiovascular risk factors