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Importantly, restricting lactylationvia glycolytic blockade, p300 inhibition, or lactate scavengingsynergized with vemurafenib to produce sustained tumor regression in 8505c xenografts with no added systemic toxicity, highlighting the glycolysislactylation axis as a druggable vulnerability that can sensitize BRAF V600E -positive ATC to targeted therapy [200]

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This R 2 increase was statistically significant, F (23, 70) = 4.114, p = 0.046