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In light of these intracellular observations (Kokame et al, 1996), we hypothesize that changes in the intracellular redox state associated with elevated homocysteine levels can alter the expression of multiple genes involved in other specific cellular functions that could be partially responsible for vascular disorders associated with moderate hyperhomocysteinemia

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Synergistic means combination exceeds sum (same example producing 70-80% benefit)

References Relevant literature includes work on BPC-157 (Sikiric P et al., Curr Pharm Des 2018

Regarding Sigma class GSTs, ApGST-S1 has previously been highlighted as the only Sigma class GST in the tapeworms secretome (Wititkornkul et al ., Reference Wititkornkul, Hulme, Tomes, Allen, Davis, Davey, Cookson, Phillips, Hegarty, Swain and Brophy2021)

doi: 10.2174/138920011796504536 31 MonacoME