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Development of techniques of tumour tissue IHC with phosphoantibodies of c-MET and its downstream signal transducers molecules would enable the validation of inhibitor efficacy in the tumour tissue itself in future clinical studies of c-MET inhibitors

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[DOI] [PubMed] [Google Scholar] 58.Janjua TI, Cao Y, Ahmed-Cox A, Raza A, Moniruzzaman M, Akhter DT, Fletcher NL, Kavallaris M, Thurecht KJ, Popat A

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58 Inflammasome activation and its role in inflammatory responses The inflammasome, a multiprotein complex, plays a central role in innate immunity and inflammatory responses by detecting cellular stress and danger signals, thereby coordinating the initiation of inflammatory pathways in response to diverse stimuli