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However, riboflavin overproduction has been achieved by obtaining mutants with overexpression of certain genes and resistance to purine analogs azaguanine, decoyinine, and methionine sulfoxide, or the riboflavin analog roseoflavin, as the B

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2.2.3 Others Metformin influences the production of advanced glycation end products (AGEs) and the generation of ROS through the activation of AMPK, inhibition of the receptor for advanced glycation end products/nuclear factor kappa B (RAGE/NF-B) signaling pathway, and modulation of gene expression