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When B12 levels drop, it can lead to fatigue, cognitive difficulties, mood imbalances, nerve problems, and even anemia

Metabolic parameters including glucose tolerance, insulin sensitivity, and IGF-1 levels were monitored throughout the treatment period, confirming that the favorable metabolic profile persisted with chronic use

Evidence Boundary Most studied route in the Phase 2 program, but the OPTIONS trial missed its primary weight-loss endpoint and development was terminated in 2007