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Endo et al., 2002)

Its effects are "accumulative" rather than "impulsive," so the onset time is measured in weeks rather than minutes or hours

652,653 Although the primary TBI caused directly by external forces is irreversible, the secondary TBI can be alleviated

PARP inhibitors impair DNA repair via PARP enzyme blockade, inducing lethal DNA damage in homologous recombination repair (HRR)-deficient tumors (e.g., BRCA1/2-mutated PCa) (Wu et al., 2021)

Thus, in order to resolve the principle behind cuprizones adverse effect, and muscle disability in particular, we argue for a direct demonstration of the healing and the recovered functionality of the severely injured muscles by trauma injury [43,44,45,46,47,48] or otherwise [10,20,21,26,28,29,51,54,55,66,71,72,73,74,75,76,77,78,79,80,81,82,102,103,104], combined with the healing of the severely injured nerves [146,147,148]

Thinking outside the cleft to understand synaptic activity: contribution of the cystine-glutamate antiporter (System xc-) to normal and pathological glutamatergic signaling