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In general, the available data from intervention trials do not support the use of supplemental B-vitamins to prevent osteoporotic fractures

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Where appropriate, referral to a specialist Tier 3 weight-management service may also be considered

Handling Notice This material should only be handled by qualified researchers in an appropriate laboratory or research setting using suitable procedures, equipment and safety precautions

For maintenance and long-term wellness, receiving an injection every two to four weeks is often sufficient

The peer-reviewed literature is also concentrated within a single research group (Watowich lab, University of Texas at Austin) and its industry partner Ridgeline Therapeutics, with limited independent replication to date