There are all sorts of interesting stuff going on there for sure
One more important point
22 DanciuC.ZupkoI.BorA.SchwiebsA.RadekeH.HancianuM.et al (2018)
It can be very difficult to watch someone you love deal with symptoms of dementia, which often include memory loss and trouble with language, along with personality changes, delusions, agitation and less ability to solve problems or control their emotions
It triggers the nonclassical nuclear factor kappa-B (NF-B) signaling pathway, produces cytokines and chemokines, promotes inflammation, and damages cellular function ( 1177 in endothelial cells (ECs) to produce nitric oxide (NO) to maintain normal endothelial function ( Intracellular hyperglycemia can increase production of advanced glycation end products (AGEs), promoting the interaction of AGEs and the advanced glycosylation end product-specific receptor (AGER, also known as RAGE)
its a well-documented risk with synthetic peptides that has ended pharmaceutical development programs