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The only placebo-controlled trial (Zubair et al., 2016) used 1,200 mg twice weekly for 6 weeks, showing only 37.5% completion rate versus 18.7% placebo, with benefits fading by 6 months

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European Review for Medical and Pharmacological Sciences, 15 (8), 931936

However, despite the aforementioned challenges it is apparent that optimizing dietary intake of glutathione precursors, co-factors, and whole foods that have been shown to enhance glutathione status or are a source of glutathione would be a relatively simple, low cost, and safe approach that could improve health by optimizing glutathione status in an individual