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Researchers at the Wellcome Trust Sanger Institute, the Los Alamos National Laboratory, and their collaborators identified several different mechanisms by which tobacco smoking causes mutations in DNA

Nicotine causes direct relaxation of LES smooth muscle, while other tobacco compounds contribute to inflammatory changes that affect sphincter competence over time

Fatigue is due to the reduction oxygen supply to the body tissues since the oxygen-carrying capacity of the lungs decreases

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When you smoke, its like those repair workers are always tired and dont have the right tools

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