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Ion pumps and exchangers are unable to keep up with the increasing concentrations of Ca 2+ , which is not pumped out of the cell, and high Ca 2+ levels trigger the release of glutamate, a major contributor to ischemia-induced excitotoxicity in neurons and glial cells (Papazian et al., 2018

While animal models have shown a favorable safety profile, and many individuals report positive experiences, the absence of extensive human clinical trials means that caution is advised

Research Evidence: advantage goes to neither (tie)

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Disorders of hemoglobin synthesis

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