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Pelicci G, Giordano S, Zhen Z, Salcini AE, Lanfrancone L, Bardelli A, et al

Expecting vision improvements within days when mechanism requires months leads to inappropriate discontinuation

Ethics declarations Conflict of interest The Authors Rosaria Maddalena Ruggeri, Camilla Virili, Edoardo Mocini, Marco Centanni, Salvatore Cannav, Mario Rotondi, Laura Croce, Silvia Migliaccio, declare no conflicts of interest

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What it is / mechanism 5-Amino-1MQ is a selective, cell-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that methylates nicotinamide (consuming the methyl donor SAM) to form 1-methylnicotinamide, diverting nicotinamide away from the NAD+ salvage pathway

The connection between systemic chronic illness and ocular manifestations is an rapidly expanding field of research