Cell-penetrating peptides: from basic research to clinics
Crizotinib, a MET inhibitor, inhibits growth, migration, and invasion of breast cancer cells in vitro and synergizes with chemotherapeutic agents
The most common adverse reactions reported in clinical trials were injection site reactions (erythema, pruritus, pain) occurring in approximately 8-13% of patients
Wahren J, Felig P, Cerasi E, Luft R (1972) Splanchnic and peripheral glucose and amino acid metabolism in diabetes mellitus
hes the reason everyone started slipping a pat of butter into their coffee a few years back
52 Again, this hasnt been observed in living animals as overt toxicity, but it underscores how a peptide that does a little of everything could have hidden downsides biochemically