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Funding This research lab was funded by iNOVA4HealthUID/Multi/04462/ a program financially supported by Fundao para a Cincia e a TecnologiaMinistrio da Educao e Cincia (FCT-MCTES), through national funds and co-funded by FEDER under the PT2020 Partnership Agreement
(2022) indicated a significant increase of basic sperm parameters including sperm concentration, total motility, progressive motility and normal forms following AOX therapy versus placebo or no treatment (100)
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The Group-I animals received a normal diet and the rest of the groups received HFD and nicotine (1.5 mg/kg, b.wt (body weight), I.P (Intraperitoneal)) (NAFLD control) and water ad libitum
Together, these data suggested that the combined action of giredestrant with GPX4 inhibition is highly active across multiple ER+ cell lines, strikingly resembling the palbociclib-GPX4 inhibition synergy
