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Acknowledgments The authors responsibilities were as follows: JZ, RY and TA wrote and reviewed the manuscript, and all authors read and approved the final manuscript

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10.1038/jcbfm.2009.262 138 ShapiraM.LichtA.MilmanA.PickC

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Future studies in larger, independent cohorts, ideally with longitudinal follow-up and integrated clinical endpoints, will be essential to determine whether the observed metabolic signatures can contribute to risk stratification, patient phenotyping, or therapeutic guidance in cardiovascular disease

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