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For that reason, DD are frequently underdiagnosed, undertreated, and can be difficult to manage ( Figure 1 Moreover, whether simultaneous or sequential, the occurrence of both disorders in one individual can affect the course and prognosis of each condition ( Neurochemistry In the case of co-occurring TUD with other mental disorders, it is possible that the same (i.e., the nicotinic-cholinergic system) or overlapping brain circuits are involved in both disorders