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The data in table 18 show that the number of sub-visible particles seen in co-formulation 18 (containing 20 mM histidine) was greater than the number of sub- visible particles seen in co-formulation 17 (containing 6 mM histidine)

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Of the 2 parallel-design trials, patients reported a preference for combination therapy in 1 trial of 130 patients (180), with no preference for combination therapy reported in another trial of 573 patients (196)