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Ignoring that this paper was specifically about psychosis, not serious mental disorders more generally, perhaps in certain high risk populations the impact of cannabis could be this high, for example in those with a genetic predisposition to psychosis, but its a big leap to conclude that from one study

Quitting smoking means learning to live without nicotines quick kick, and nicotines effects on the brains reward center can make quitting difficult

This reflects a similar national trend

Severe asthmatics were characterized by enrichment of Aspergillus

other drugs The experience of a drug high is individual and difficult to test scientifically